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Abstract #3640

Associations of Metabolite Concentration and Water Diffusivity in Normal Appearing Brain Tissue with Glioma Grade

Andrew A. Maudsley1, Bhaswati Roy2, Rakesh K. Gupta2, Sulaiman Sheriff1, Rishi Awasthi2, Meng Gu3, Nuzhat Hussain4, Sudipta Mohakud2, Sanjay Behari2, Daniel Spielman3

1Radiology, University of Miami, Miami, FL, United States; 2Radiodiagnostics, SGPGIMS, Lucknow, Uttar Pradesh, India; 3Radiology, Stanford University, Stanford, CA, United States; 4Pathology, Ram Manohar Lohia, Institute of Medical Sciences, Lucknow, Uttar Pradesh, India

This study reports changes of tissue metabolism, determined using 1H 3D MRSI, and ADC in tissue regions that are remote from the lesion and appear normal on conventional MRI for subjects with glioma. The associations of these changes with tumor grade are reported.