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Abstract #3645

Phospholipid Metabolism Before and During Bevacizumab Therapy in Recurrent Glioma

Ulrich Pilatus1, Oliver Br2, Johannes Rieger2, Stefanie Pellikan1, Maurice Harth1, Joachim Steinbach2, Elke Hattingen1

1Institute of Neuroradiology, Goethe-University Frankfurt, Frankfurt, Germany; 2Dr. Senckenbergisches Institut fr Neuroonkologie, Goethe-University Frankfurt, Frankfurt, Germany

31P and 1H MRSI was used to monitor changes in phospholipid and energy metabolism in recurrent gliomas during antiangiogenic therapy. Elevated PEth/GPE ratios were typical for all recurrent gliomas while high PCho/GPC ratios correlated with the survival time. Both anabolite/katabolite ratios decreased upon onset of therapy. Energy metabolism, mesures as PCr/Pi ratio, was deprived in tumor tissue.