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Abstract #3647

Multi-Compartment Diffusion Analysis for Differentiation of Malignant and Benign Brain Tumors in Pediatric Patients

Jie Deng1, 2, Delilah Burrowes1, Emma Boylan1

1Medical Imaging, Ann & Robert H. Lurie Childrens Hospital of Chicago , Chicago, IL, United States; 2Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States

This pilot study was to evaluated the anomalous diffusion model and bi-exponential two-compartment model using extended b-value (0-3500 s/mm2) DWI, in differentiation of malignant and benign tumors in pediatric patients. Multiple diffusion parameters including space constant &[mu], complex parameter &[beta], extracellular diffusion coefficient (Dfast) and volume (Vfast) and intracellular diffusion coefficient (Dslow) and volume (Vslow) were derived from these two models. This study shows a strong correlation in differentiating malignant and benign brain tumor types using simultaneous evaluation of multiple diffusion parameters. This method may prove to be useful in improving the accuracy and confidence in the diagnosis of various brain tumors,