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Abstract #3659

Diffusion Tensor Markers of the Neurobiology of Cocaine Addiction

Khader M. Hasan1, MA Liangsuo2, Larry A. Kramer1, Scott D. Lane2, Joel S. Steinberg2, Ponnada A. Narayana1, Gerry F. Moeller2

1Diagnostic and Interventional Imaging, University of Texas Health Science Center at Houston, Houston, TX, United States; 2Psychiatry and Behavioral Sciences, University of Texas Health Science Center at, Houston, TX, United States

In this work we applied atlas-based methods to identify the macro and microstructural correlates of cocaine effects by incorporating white matter (WM) connections in addition to the limbic-thalamic-striatal-cortical regions as previously reported. Our study indicates that GM mean diffusivity of the cingulate cortex and thalamus may serve as early markers that could precede subsequent long term effects of cocaine on WM pathways.