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Abstract #3662

Evaluation of the Impact of White Matter Lesion on the Fractional Anisotropy Maps in Alzheimers Disease Patients and Normal Healthy Controls

Keumsil Lee1, Daniel H.-E. Chang1, Huali Wang2, Min-Ying Su1

1Center for Functional Onco-Imaging, Department of Radiological Sciences, University of California, Irvine, CA, United States; 2Department of Geriatric Psychiatry, Peking University Institute of Mental Health, Beijing, China

The impact of white matter lesion (WML) on FA maps is studied. We selected a group of AD patients without WML based on the Age-Related White Matter Changes (ARWMC) rating scale of the European Task Force, and another group of AD patients with severe WML for comparison. The AD subjects with severe WML show smaller differences compared to normal control (NC), while the AD subjects without WML show a more extensive difference compared to the NC. The results suggest that the AD group containing white matter lesions have more heterogeneity white matter abnormality, thus less likely to show significant differences.