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Abstract #3696

Real-Time MRI of Tablet Disintegration: Visualization and Quantification

Amir Moussavi1, 2, Julian Quodbach3, Jens Frahm, 24, Roland Tammer1, 2

1Biomedizinische NMR Forschungs GmbH, am Max-Planck-Institut fr biophysikalische Chemie, Gttingen, Niedersachsen, Germany; 2DFG Research Center for Molecular Physiology of the Brain (CMPB), Gttingen, Niedersachsen, Germany; 3Institut fr Pharmazeutische Technologie und Biopharmazie, Heinrich-Heine-Universitt Dsseldorf, Dsseldorf, NRW, Germany; 4Biomedizinische NMR Forschungs GmbH, Max Planck Institute, Gttingen, Niedersachsen, Germany

The efficiency of orally administered pharmaceutical dosage forms depends on the disintegration characteristics of the tablet. In contrast to conventional approaches that only observe the surface of tablets during the disintegration process via CCD cameras, the real-time MRI-based method proposed in this work is able to visualize the interior of disintegrating tablets. The achieved spatiotemporal resolution with real-time MRI is sufficient to get a detailed representation of the disintegration dynamics. Furthermore, the introduced method is able to determine the disintegration time of tablets.