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Abstract #3721

Quantitative Oxygenation Venography from MRI Phase

Audrey Peiwen Fan1, Berkin Bilgic1, Louis O. Gagnon2, 3, Thomas Witzel3, Himanshu Bhat3, Bruce R. Rosen2, 3, Elfar Adalsteinsson1, 3

1Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States; 2Health Sciences and Technology, Harvard-MIT, Cambridge, MA, United States; 3Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States

Comprehensive venograms which map quantitative oxygenation along each vessel are shown for the first time. Susceptibility maps are created from MR phase images and cerebral veins are graphed into a node-edge representation. Quantitative oxygen saturation (SvO2) along each vessel is then displayed onto a 3D mesh generated from the graph to create oxygenation venograms. We probe the dependence of reconstructed SvO2 in vivo as a function of vein tilt angle relative to the main field, and found increased SvO2 at angles undersampled by the dipole imaging kernel. This observation motivates future work to incorporate vessel angle priors from graphing for more accurate model-based reconstruction of SvO2 venograms.