Abstract #3730

Non-Rigid Registration of Sequential DCE-MRI in the Assessment of Response to Neoadjuvant Chemotherapy in Breast Cancer

Tess E. Catherwood¹, Andrew J. Patterson¹, Kamarul Zaki², Mahesh Iddawela², Helena Earl², Carlos Caldas³, Karen Sayal⁴, Martin John Graves¹, Fiona J. Gilbert¹

¹Radiology, University of Cambridge, NHS Foundation Trust, Cambridge, United Kingdom; ²Oncology, Addenbrooke's Hospital and University of Cambridge, NHS Foundation Trust, Cambridge, United Kingdom; ³Cancer Research UK Cambridge Institute, Cambridge, United Kingdom; ⁴University of Cambridge, Cambridge, United Kingdom

Tumor heterogeneity is well recognized in breast cancer and is associated with differential responses to chemotherapy. Voxel-wise analysis of sequential DCE-MRI requires that images be spatially registered. Patients were studied with 3T MRI during neoadjuvant chemotherapy. Mutual information-based rigid and non-rigid registration was used to align dynamic and sequential volumes to account for motion artifacts and larger inter-session deformations. Semi-quantitative perfusion metrics were extracted and generation of spatially registered parameter maps allowed voxel-wise assessment of treatment response. This approach provides an insight into tumor microstructure and physiology and developments will ideally increase statistical sensitivity in differentiating responders and non-responders.