Abstract #3855

A Quantitative Susceptibility Mapping (QSM) Analysis in Subjects with Alzheimers Diseases and Mild Cognitive Impairment

Eo-Jin Hwang¹, Min-Ji Kim², Hyug-gi Kim³, Kyung-Mi Lee⁴, Ji-Seon Park, Wook Jin², Dal-Mo Yang², Geon-Ho Jahng²

¹Kyung Hee University Hospital at Gangdong, Seoul, Korea; ²KyungHee University Hospital at GangDong, Seoul, Korea; ³KyungHee University, YoungIn, Gyeonggi-do, Korea; ⁴Department of Radiology, Kyung Hee University Hospital, Seoul, Korea

The objective of this study was to apply voxel-based analyses to compare the susceptibility changes among three different groups, cognitive normal (CN), mild cognitive impairment (MCI), and Alzheimers disease (AD) using a quantitative susceptibility mapping (QSM) technique. The QSM images were produced by implementing a Morphology Enabled Dipole Inversion (MEDI) method, and the direct comparisons of the whole brains between CN and MCI, CN and AD, and MCI and AD subjects were performed. Throughout the study, the brain regions where different susceptibility effects existed were identified, and the effects of both paramagnetic and diamagnetic substances were visible in all comparisons.