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Abstract #3862

in vivo Magnetic Resonance Imaging of Activity-Dependent Neural Progenitor Cell Migration

Nikorn Pothayee1, Diana Cummings2, Leonardo Belluscio2, Alan P. Koretsky1

1Laboratory of Functional and Molecular Imaging, NINDS/NIH, Bethesda, MD, United States; 2Developmental Neural Plasticity Section, NINDS/NIH, Bethesda, MD, United States

Neural progenitor cells (NPCs) are produced throughout life by neural stem cells in the subventricular zone (SVZ). NPCs migrate from the SVZ through the rostral migratory stream (RMS) to the olfactory bulb (OB), where they differentiate into various types of interneurons. Herein, we use cellular MRI to investigate potential role of olfactory sensory input on the rate and pattern of NPC migration.