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Abstract #3870

Evaluation of the Concentration of Lanthanide Ions in ex vivo Mouse Tissue Using BMS NMR Spectroscopy

Sandra I. Gonzalez1, Dina V. Hingorani2, Marty Pagel1, 2

1Biomedical Engineering, University of Arizona, Tucson, AZ, United States; 2Chemistry & Biochemistry, University of Arizona, Tucson, AZ, United States

The evaluation of lanthanide-based MRI contrast agents often requires the quantification of concentrations of the agents in ex vivo tissues to validate in vivo results. We have developed a BMS NMR spectroscopy method that can quantify the concentrations of lanthanide-based agents in ex vivo tissues, which has an outstanding yield of 93, excellent precision within ~1 mM, and acceptable sensitivity approaching 0.1 mM.