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Abstract #3885

Dendrimeric Paramagnetic Chelates for BIRDS

Yuegao Huang1, 2, Meser M. Ali3, Daniel Coman1, 2, Garry E. Kiefer4, Fahmeed Hyder1, 5

1Diagnostic Radiology, Yale University, New Haven, CT, United States; 2Magnetic Resonance Research Center, Yale University, New Haven, CT, United States; 3Radiology, Henryford Health System, Detroit, MI, United States; 4Macrocyclics, Dallas, TX, United States; 5Biomedical Engineering, Yale University, New Haven, CT, United States

Temperature mapping using low molecular weight paramagnetic chelates has advantageous sensitivities compared to conventional MRI thermometry methods. 3D temperature maps can be generated with a method called Biosensor Imaging of Redundant Deviation in Shifts (BIRDS), where directly imaging proton resonances of lanthanide complexes with 3D CSI is key. Considering success of BIRDS with low molecular weight individual chelates, in the present work we explore the possibilities to improve BIRDS sensitivity with larger biocompatible molecules, such as dendrimers. The BIRDS detection can be achieved with lower agent dosage when lanthanide chelates are conjugated to the surface of the dendrimers.