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Abstract #3892

A R2p/R1p Ratiometric Approach with Gd Containing Liposomes for the Imaging of Matrix Metalloproteinases by MRI

Giuseppe Digilio1, Valeria Catanzaro2, Valeria Menchise3, Sergio Padovan3, Martina Capozza4, Linda Chaabane5, Silvio Aime4

1Universit del Piemonte Orientale "A. Avogadro", Alessandria, AL, Italy; 2Istituto di Ricerca Diagnostica e Nucleare SDN, Via Gianturco 113, Napoli, 80143, Na, Italy; 3CNR - IBB, Torino, TO, Italy; 4Department of Chemisty & Center for Molecular Imaging,, University of Turin, Torino, TO, Italy; 5Institute for Experimental Neurology - INSpe, San Raffaele Scientific Institute, Milano, MI, Italy

A novel paramagnetic Gd-loaded liposome for the MRI assessment of the activity of Matrix Metalloproteinase-2 is described. It relies on a ratiometric R2p/R1p procedure that is independent of the total concentration of gadolinium.