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Abstract #3905

MR Imaging of ex-vivo Mouse Joints on a Clinical 3T System with Diagnostic SPION Imaging Using DUTE in an Arthritis Model.

Lindsey Alexandra Crowe1, Frank Tobalem2, Marije Koenders3, Eline Vermeij3, Fons A. van de Loo3, Azza Gramoun1, Jatuporn Salaklang4, Anthony Redgem4, Alke Petri-Fink5, Heinrich Hofmann6, Wim van der Berg3, Jean-Paul Valle1

1Radiology / Faculty of Medicine, Geneva University Hospital, Geneva, Switzerland; 2Radiology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; 3Department of Rheumatology, Rheumatology Research and Advanced Therapeutics,, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands; 4Adolphe Merkle Institute, Universit de Fribourg, Fribourg, Switzerland; 5Adolphe Merkle Institute and Chemistry Departement, Universit de Fribourg, Fribourg, Switzerland; 6Institute of Materials, Powder Technology Laboratory, EPFL, Lausanne, Switzerland

Many pre-clinical studies are carried out on clinical MRI systems due to translational possibilities and availability of technology. For small sample sizes, an adapted coil to give high signal intensity is needed. Diagnostic potential of signal loss and positive contrast difference Ultrashort Echo (dUTE) sequences for iron oxide nanoparticle detection (amino-PVA-SPIONs) was compared in a mouse model of antigen induced arthritis. SPION administration routes and doses in arthritic and control knees are compared for synovial uptake with high sample throughput.