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Abstract #3911

Investigation of Substrate Dose on Rat Cardiac Metabolism in Vivo Using MRS of Hyperpolarized [2-13C]pyruvate

Sonal Josan1, 2, Jae Mo Park2, Yi-Fen Yen2, Ralph Hurd3, Adolf Pfefferbaum1, 2, Daniel Spielman2, Dirk Mayer1, 2

1SRI International; 2Stanford University; 3GE Healthcare

Hyperpolarized [1-13C]-pyruvate MRS has been used to measure changes in cardiac PDH flux via measurement of 13C-bicarbonate, but may not reflect tricarboxylic acid (TCA) cycle activity.