Abstract #3915

Comparison of Tumor Perfusion Measured by Hyperpolarized 13C Urea with DCE MR Imaging Prior to and Following Radiation Therapy

Vickie Zhang¹,², Robert A. Bok³, Jessie Lee², Subramaniam Sukumar¹, Adam Cunha⁴, I-Chow Hsu⁴, Jean Pouliot⁴, Daniel B. Vigneron¹,², John Kurhanewicz¹,²

¹Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States; ²Graduate Program in Bioengineering, University of California, San Francisco & University of California, Berkeley, Berkeley, CA, United States; ³Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States; ⁴Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA, United States

Dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) has shown great clinical potential for assessing prostate cancer presence and aggressiveness prior to and after radiation therapy. Co-polarization of 13C pyruvate and urea also allows the simultaneous assessment of tumor perfusion and metabolism in a single MR acquisition (3,4). However, whether hyperpolarized 13C urea provides the same information as DCE MRI remains to be answered. This study investigated tumor perfusion prior to therapy and following radiation therapy in a transgenic murine model of prostate cancer using both HP 13C urea and DCE-MRI.