Ulrich Kllisch1,
Rolf F. Schulte2, Markus Durst1, Jan Henrik
Ardenkjaer-Larsen3, Francesca Frijia4, Luca Menichetti5,
Massimo Lombardi4, Axel Haase1, Florian Wiesinger2
1Institute
of Medical Engineering, Technische Universitt Mnchen, Garching, Germany; 2GE
Global Research, Garching, Germany; 3GE Healthcare, Brndby,
Denmark; 4Fondazione CNR-Regione Toscana G.Monasterio, Pisa,
Italy; 5Institute of Clinical Physiology of CNR, Pisa, Italy
Metabolic imaging with hyperpolarized [1-13C]pyruvate has high potential for examination of myocardial viability. In this work a 3D cardiac sequence for imaging the metabolism of hyperpolarized [1-13C]pyruvate over the whole porcine heart is presented. Therefore a multiband pulse was implemented using the polarization very efficiently. The results demonstrate, that the presented acquisition scheme is feasible for [1-13C]pyruvate metabolic imaging by accurately depicting pyruvate lactate and bicarbonate distributions over the entire left ventricle.