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Abstract #3926

Detecting and Characterizing Therapeutic Response to Radio- & Chemotherapies with Hyperpolarized [1-13C] Pyruvate in Rat Glioma Model

Heeseung Lim1, Kundan Thind1, Timothy Pok Chi Yeung1, 2, Francisco M. Martinez-Santiesteban1, Timothy J. Scholl1, 3

1Medical Biophysics, Western University, London, Ontario, Canada; 2London Regional Cancer Program, LHSC, London, Ontario, Canada; 3Imaging Research Laboratories, Robarts Research Institute, Western University, London, Ontario, Canada

This study monitors the effects of radio- and chemotherapy on glioblastoma multiforme in a rat model through chemical-shift imaging of hyperpolarized [1-13C]pyruvate. Preliminary results suggest that both radiotherapy and chemotherapy alter tumor metabolism (determined by the observed lactate-to-pyruvate ratio) as early as 2 days after treatment. Seven days after treatment, the lactate-to-pyruvate ratio in tumors was similar to healthy tissue. Response to therapy was more immediate for tumours receiving radiotherapy. Further animal studies will better quantify the time course of therapeutic response and to investigate the effects of combined therapies.