Abstract #3931

Frequency Band-Selective Spiral CSI: Application to Imaging Cardiac Metabolism with Hyperpolarized [2-13C]pyruvate

Sonal Josan¹,², Ralph Hurd³, Yi-Fen Yen², Adolf Pfefferbaum¹,⁴, Daniel Spielman², Dirk Mayer¹,²

¹SRI International, Menlo Park, CA, United States; ²Radiology, Stanford University, Stanford, CA, United States; ³GE Healthcare; ⁴Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, United States

Spectroscopic imaging with hyperpolarized ¹³C substrates has been widely used to measure metabolic processes in real time in vivo. There has been growing interest recently in using hyperpolarized [2-¹³C]pyruvate, to follow the ¹³C label into metabolic products including glutamate (in exchange with α-ketoglutarate in the TCA cycle), citrate, acetyl-carnitine and acetoacetate as well as lactate and alanine. CSI with [2-¹³C]Pyr is challenging given the wide spectral dispersion of the resonances. This work uses a spectrally selective excitation to perform 3D CSI of spectral sub-bands containing metabolites of interest. Dynamic data is acquired from multiple sub-bands alternately in vivo in rat heart.