Abstract #3938

Fast 3D Spiral Chemical Shift Imaging of Mitochondrial Metabolism in Brain with C6 Glioma Using Hyperpolarized [2-13C]Pyruvate

Jae Mo Park¹,², Sonal Josan,¹³, Taichang Jang⁴, Milton Merchant⁴, Ronald D. Watkins¹, Yi-Fen Yen¹, Ralph Hurd⁵, Lawrence Recht⁴, Daniel Spielman¹,², Dirk Mayer¹,³

¹Radiology, Stanford University, Stanford, CA, United States; ²Electrical Engineering, Stanford University, Stanford, CA, United States; ³Neuroscience Program, SRI International, Menlo Park, CA, United States; ⁴Neurology and Neurological Science, Stanford University, Stanford, CA, United States; ⁵Applied Science Laboratory, GE Healthcare, Menlo Park, CA, United States

We developed a fast volumetric chemical shift imaging sequence for imaging of hyperpolarized [2-13C]Pyruvate and its products, without suffering chemical shift displacement artifact due to the large spectral dispersion of [2-13C]Pyruvate and its products, and applied it to measuring brain metabolism in healthy and C6 glioma-bearing rats.