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Abstract #3938

Fast 3D Spiral Chemical Shift Imaging of Mitochondrial Metabolism in Brain with C6 Glioma Using Hyperpolarized [2-13C]Pyruvate

Jae Mo Park1, 2, Sonal Josan, 13, Taichang Jang4, Milton Merchant4, Ronald D. Watkins1, Yi-Fen Yen1, Ralph Hurd5, Lawrence Recht4, Daniel Spielman1, 2, Dirk Mayer1, 3

1Radiology, Stanford University, Stanford, CA, United States; 2Electrical Engineering, Stanford University, Stanford, CA, United States; 3Neuroscience Program, SRI International, Menlo Park, CA, United States; 4Neurology and Neurological Science, Stanford University, Stanford, CA, United States; 5Applied Science Laboratory, GE Healthcare, Menlo Park, CA, United States


We developed a fast volumetric chemical shift imaging sequence for imaging of hyperpolarized [2-13C]Pyruvate and its products, without suffering chemical shift displacement artifact due to the large spectral dispersion of [2-13C]Pyruvate and its products, and applied it to measuring brain metabolism in healthy and C6 glioma-bearing rats.

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