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Abstract #3940

Hyperpolarization of Drugs Using Signal Amplification by Reversible Exchange (SABRE)

Haifeng Zeng1, Jiadi Xu2, Joseph Gillen, 12, Michael T. McMahon, 12, Dmitri Artemov1, Jean-Max Tyburn3, Joost Lohman4, Ryan Mewis5, Kevin Atkinson5, Simon Duckett5, Peter C.M. van Zijl, 12

1Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States; 2F.M.Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States; 3Bruker BioSpin GmbH, Silberstreifen, Rheinstetten, Germany; 4Bruker UK Limited, Banner Lane, Coventry, United Kingdom; 5Department of Chemistry, University of York, Heslington, York, United Kingdom

Here we investigated the possibility to use SABRE to polarize several drugs used daily in the clinic. These are isoniazid and pyrazinamide used for treating tuberculosis (TB) and temozolomide for treating brain tumors.