Abstract #3972

J-Difference Editing of GABA: Simulated and Experimental Multiplet Patterns

Richard Anthony Edward Edden¹,², Jamie Near³, C. John Evans⁴, Nicolaas A. J. Puts,²⁵, Peter B. Barker¹,²

¹Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States; ²F. M. Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States; ³Douglas Mental Health University Institute and Department of Psychiatry, McGill University, Montreal, Quebec, Canada; ⁴CUBRIC, School of Psychology, Cardiff University, Cardiff, Wales, United Kingdom; ⁵Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States

In this abstract, we investigate factors that influence the multiplet pattern observed in J-difference editing of GABA. Density matrix simulations were applied to investigate the shape of the 3 ppm multiplet as a function of the editing sequences slice-selective refocusing pulse properties, in particular bandwidth, transition width, and flip angle.