Richard Anthony Edward Edden1, 2, Jamie Near3, C. John Evans4, Nicolaas A. J. Puts, 25, Peter B. Barker1, 2
1Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States; 2F. M. Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States; 3Douglas Mental Health University Institute and Department of Psychiatry, McGill University, Montreal, Quebec, Canada; 4CUBRIC, School of Psychology, Cardiff University, Cardiff, Wales, United Kingdom; 5Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States
In this abstract, we investigate factors that influence the multiplet pattern observed in J-difference editing of GABA. Density matrix simulations were applied to investigate the shape of the 3 ppm multiplet as a function of the editing sequences slice-selective refocusing pulse properties, in particular bandwidth, transition width, and flip angle.