Two-Dimensional Semi-LASER Correlated Spectroscopy with Well-Maintained Cross-Peaks

Meijin Lin¹, Anand Kumar¹, Shaolin Yang¹, ²

Two-dimensional (2D) localized chemical shift correlated spectroscopy (L-COSY) is one of the simplest and the most useful methods applied for 2D magnetic resonance spectroscopy (MRS). L-COSY spectra provide more separated peaks with cross-peaks for spectral quantification. Keeping the cross-peak intensities from attenuation is critical for reliable and accurate quantification of metabolites. In this abstract, however, we demonstrated that using limited-bandwidth (BW) of radiofrequency (RF) pulses for slice selection might attenuate the intended cross-peaks in L-COSY spectra. We further demonstrated using semi-localization by adiabatic selective refocusing (sLASER) pulses for localization in COSY can maintain the intended cross-peaks from attenuation.