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Abstract #3979

Fast Whole Brain Quantitative Proton Density Mapping to Normalize 1H MR Spectroscopic Imaging

Angle Lecocq1, Yann Le Fur2, Alexis Amadon3, Alexandre Vignaud3, Monique Bernard4, Maxime Guye1, Jean-Philippe Ranjeva1

1CRMBM, CNRS, Aix-Marseille Univ, MARSEILLE, France; 2CRMBM, CNRS, Aix-Marseille Univ,, MARSEILLE, France; 3LRMN/NeuroSpin/I2BM/CEA, GIF SUR YVETTE, France; 4Aix-Marseille Universit, MARSEILLE, France

In order to normalize CSI water spectrum to obtain signal normalized MR spectroscopic imaging, absolute ρ-maps have to be computed from T1 and T2* maps accounting for B0 and B1 corrections. In this work, we present a very fast method to generate these ρ-maps. A method called XEP recently proposed to obtain fast B1-maps, was combined with a DESPOT1 sequence, an optimized variable flip angle T1 mapping sequence and a conventional T2* mapping sequence. We first validated this method on phantom, and determined proton density maps in three healthy volunteers also explored by CSI technique.