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Abstract #3985

Glx Measured by J-Editing/MEGA-PRESS Is Primarily Pure GlutamateOr Is It?

Dikoma C. Shungu1, Xiangling Mao1, Meng Gu2, Matthew S. Milak3, Nora Weiduschat1, Dirk Mayer, 24, Daniel Spielman2, J. John Mann3, Lawrence S. Kegeles3

1Radiology, Weill Cornell Medical College, New York, NY, United States; 2Radiology, Stanford University, Stanford, CA, United States; 3Psychiatry, Columbia University, New York, NY, United States; 4SRI International, Menlo Park, CA, United States

This study was undertaken to investigate the contribution of glutamine (Gln) to the combined glutamate (Glu)+Gln resonance (Glx) that is detected by the standard J-editing/MEGA-PRESS sequence. Toward this purpose, spectra of pure Glu were acquired with CT-PRESS and those of Glx were acquired with J-editing from the same voxels, in the same subjects, to assess the extent to which the two measures may correlate. A strong correlation would suggest that Glx likely represents primarily "pure" Glu levels and, thus, can probably be interpreted as such.