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Abstract #4009

In Vivo 3D Spectroscopic Imaging of 19F Compounds Using Backprojection

Muhammed Yildirim1, 2, Raquel Daz-Lpez3, Klaas Nicolay2, Rolf Lamerichs3, 4

1MR Development, Advanced Diagnostic Imaging, Philips Healthcare, Best, Netherlands; 2Biomedical NMR, Eindhoven University of Technology, Eindhoven, Netherlands; 3Philips Research, Eindhoven, Netherlands; 4Academic Medical Center, Amsterdam, Netherlands

Combination of Fluorine ultrafast Turbo Spectroscopic Imaging (F-uTSI) sequence with backprojection acquisition and reconstruction allows 3D fluorine hot-spot images to be obtained in shorter times and with higher sensitivity in comparison to all phase encoded 3D acquisition. The technique has been used to image orally administered perfluoro octyl bromide (PFOB) containing polymeric microcapsules in the gastro-intestinal tract of black mice. In vivo results revealed a scan time reduction of 40% and SNR gain up to 75%, with excellent spatial resolution of 1 mm along all imaging axes.