A Novel Method to Obtain High Resolution 2D MRS Through 3D Acquisition Under Large Inhomogeneous Magnetic Fields

Yanqin Lin¹, Liandi Zhang¹, Shuhui Cai¹, Zhong Chen¹

High resolution magnetic resonance spectroscopy (MRS) plays an important role in in vivo study. However, in many cases, the inherent heterogeneity of the samples or living organisms under investigation leads to field fluctuations and losses of local homogeneity. This would degrade spectral quality. Here, a pulse sequence based on coherence transfer and spin echo is designed to obtain high-resolution 2D MRS in the presence of large field inhomogeneity. The resulting spectrum display chemical shift differences and J coupling splitting in two orthogonal dimensions. The technique developed here can be applied potentially for in vivo high resolution MRS under inhomogeneous field.