Left-Right Bias in Triglyceride Composition of Adipose Tissue Measured by 1H MRS

Gavin Hamilton¹, Michael S. Middleton¹, Claude B. Sirlin¹

In vivo Proton Magnetic Resonance Spectroscopy (¹H MRS) can quantity the composition of triglyceride in adipose tissue in the human body. In this study we examine whether, at clinical filed strengths (3T), the location of the MRS voxel within the body has an effect on spectral uniformity and hence the measured composition of triglyceride, and whether using a reduced spectral range removes spatially introduced bias. We find using the full fat spectrum to measure triglyceride composition introduces a left-right bias which is removed if the fat peaks in the 0.5-3.0 ppm range are used.