Abstract #4040

Glutamate, GABA and NAAG in Medicated Patients with Obsessive-Compulsive Disorder

Mona A. Mohamed¹, Nicolaas A. J. Puts¹, James Robert Brasic², Manuel O. Uy³, Jarunee Intrapiromkul¹, Gerald Nestadt⁴, Richard Anthony Edward Edden⁵, Peter B. Barker⁵

¹The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD, United States; ²Radiology, Johns Hopkins Medical Institutions, Baltimore, MD, United States; ³Applied Physics Laboratory, JHU, Laurel, MD, United States; ⁴Psychiatry, Johns Hopkins Medical Institutions, Baltimore, MD, United States; ⁵The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States

Through magnetic resonance spectroscopy (MRS) editing technique for GABA, NAA and NAAG, our findings suggests that there is no significant differences found in these brain metabolites concentrations in the anterior cingulate cortex (ACC) or the basal ganglia/thalamus (BG/TH) regions of OCD patients as compared to controls.