Caroline L. Hoad1, Helen Parker2, Emily Tucker2, Carolyn Costigan1, Eleanor F. Cox1, Luca Marciani2, Mark R. Fox2, Penelope A. Gowland1
1Sir Peter Mansfield Magnetic Resonance Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom; 2Biomedical Research Unit in Gastrointestinal and Liver Diseases, Nottingham University Hospital NHS Trust and University of Nottingham, Nottingham, Nottinghamshire, United Kingdom
This study describes an MRI technique to estimate gastric secretions after ingestion of a nutrient test meal. Gastric secretions were estimated from T1 maps generated from IR-EPI data in the body of the stomach and in-vitro calibration data which diluted the Gd-DOTA doped test meal with simulated gastric secretions. Good agreement was found between estimated gastric secretion volume and secretion layer and &[kappa] a parameter used in a model of gastric emptying which reflects the early changes in volume due to secretion and emptying. A lower &[kappa] was seen in functional dyspepsia patients with no change in secretion volume observed.