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Abstract #4058

Effect of Mesenchymal Stem Cells on the Vascularization of the Artificial Cavity Used as a Site for Islet Transplantation

Daniel Jirak1, Jan Kriz1, Peter Girman1, Eva Vodraskova1, Klara Zacharovova1, Eva Dovolilova1, Vit Herynek1, Frantisek Saudek1, Milan Hajek1

1Institute for Clinical and Experimental Medicine, Prague, Czech Republic

To improve transplantation outcomes, artificial sites for islet transplantation are tested. The aim of our study was to evaluate the effect of mesenchymal stem cells on the blood supply of the artificial cavities for islet transplantation created subcutaneously or within the greater omentum in a preclinical rat model. Neovascularization within biocompatible devices with/without mesenchymal stem cells was assessed during the four weeks following implantation by dynamic contrastenhanced magnetic resonance imaging. Our results indicate that artificial device containing the mesenchymal stem cells provides superior blood supply for the transplanted cells and longer optimal time for cell transplantation.