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Abstract #4064

MR Imaging and Spectroscopic Investigation of Exercise and Calorie Restriction in High Fat Diet Fed Obese Rats

Venkatesh Gopalan1, S. Ishino2, S.S. Lee1, Y.A. Yang3, Bhanu Prakash KN1, Z. Zhou3, M. Kaneko2, Y. Nakano2, M. Watanabe2, T. Horiguchi2, B. Zhu3, Sendhil S. Velan1

1Laboratory of molecular Imaging, Singapore Bioimaging Consortium, Singapore, Singapore; 2Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan; 3Takeda Singapore Pte. Limited, Singapore, Singapore

Influence of exercise and calorie restriction on obese rats was studied using MR imaging and spectroscopy. The rats were fed with high fat diet D12079B. Animals were grouped (n=7/group) as control, calorie restriction (mild and severe) and exercise (mild and severe). All experiments were performed on a 7T MRI/MRS scanner. Rats were scanned at pre- and post-intervention stages. Calorie restriction and exercise group showed significant reduction in SAT, VAT and liver fat and was correlated to the blood analysis.