Abstract #4075

Separate Assessment of Fibrosis, Steatosis and Inflammation: Multi-Parametric Imaging of Chronic Liver Diseases

Sabrina Doblas¹, Helena S. Leitao¹,², Philippe Garteiser¹, Gaspard d'Assignies¹,³, Feryel Mouri⁴, Valrie Vilgrain¹,³, Ralph Sinkus¹, Carlos F.G.C. Geraldes², Bernard E. Van Beers¹,³

¹U773-CRB3, INSERM, Paris, France; ²Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; ³Radiology Department, Beaujon University Hospital, Clichy, France; ⁴Hepatology Department, Beaujon University Hospital, Clichy, France

Confounding factors such as steatosis and inflammation can bias the evaluation of hepatic fibrosis by MR elastography or DWI, 2 techniques proposed as non-invasive approaches to the evaluation of chronic liver diseases. Multivariate analysis of MR elastography and DWI data obtained from a cohort of 58 hepatitis patients showed that viscoelastic parameters preferentially responded to fibrosis, whereas the diffusion coefficient was mostly affected by steatosis.