Dynamic Hepatospecific Contrast Enhanced-MRI with Gd-EOB-DTPA: Correlation Between MR Quantitative Parameters and Hepatocyte Transporter Expression

Matthieu Lagadec¹, Sabrina Doblas¹, Celine Giraudeau¹, Jean-Luc Daire¹, Simon Auguste Lambert¹, Magali Fasseu¹, Valerie Paradis¹, Richard Moreau¹, Bernard E. Van Beers¹

The hepatic function is important to assess in liver cirrhosis because it has both prognostic and therapeutic implications. This study aims at evaluating the relationship between Dynamic hepatospecific contrast enhanced-MRI with Gd-EOB-DTPA with hepatocyte transporter expression. MRI data was analyzed quantitatively through deconvolution analysis to determine the hepatic extraction fraction and the input relative blood flow. Our results show that the hepatic functional parameters determined at Gd-EOB-DTPA enhanced MRI correlate with the changes of hepatocyte transporters of the OATP1-MRP and NTCP systems in liver cirrhosis and suggest that the extraction fraction of Gd-EOB-DTPA is a marker of the decreased hepatocyte uptake function in liver cirrhosis