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Abstract #4118

Dynamic Ventilation 3He MRI of Human Lung: Correlations and Reproducibility Study Using Free-Breath Administration with Volumetric Bolus Monitoring

Maxim Terekhov1, Klaus Gast2, Manuela Gueldner3, Julien Rivoire1, Ursula Wolf2, Janet Friedrich1, Sergej Karpuk3, Laura Maria Schreiber1

1Department Radiology, Section of Medical Physics, Johannes Gutenberg University Medical Center Mainz, Mainz, Germany; 2Department of Radiology, Johannes Gutenberg University Medical Center Mainz, Mainz, Germany; 3Institute of Physics, Johannes Gutenberg University, Mainz, Germany

Dynamic Ventilation of lung measured with hyperpolarized 3He-MRI (3He-DV-MRI) is an efficient tool to obtain information on temporal and spatial distribution of gas in lung airways and parenchyma, that is of great importance for the diagnostics of airways obstructions e.g. asthma and COPD. We performed systematic study and analysis of correlations and reproducibility between the parameters of applied 3He-bolus and gas delivery as measured by 3He-DV-MRI. The study was done on n=10 healthy volunteers with flow-controlled gas administration using custom-built application unit (AU). To our knowledge this is one of the first studies with validation of 3He-DV-MRI by the volumetry data on a large group of volunteers.