Abstract #4123

Amide Proton Transfer (APT) Imaging of Uterine Tumors: A Preliminary Clinical Study

Yukihisa Takayama¹, Akihiro Nishie², Osamu Togao¹, Yoshiki Asayama², Yasuhiro Ushijima², Nobuhiro Fujita², Takashi Yoshiura², Makoto Obara³, Jochen Keupp⁴, Hiroshi Honda²

¹Department of Molecular Imaging and Diagnosis, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; ²Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; ³Philips Electronics Japan, Tokyo, Japan; ⁴Philips Technologie GmbH Forschungslaboratorien, Hamburg, Germany

In this study, we investigated the feasibility of CEST imaging for the assessment of uterine tumors; endometrial carcinoma (EMCA) and squamous cell carcinoma (SCC). Our results showed that the spectra of MTRasym of EMCA were significantly higher than those of SCC at from 2.2 ppm to 3.7 ppm and from 4.8 ppm to 5.1 ppm. In addition, amide proton transfer (APT) map showed that APT ratio of EMCA was significantly higher than that of SCC. CEST imaging of uterine tumor may be feasible in clinical practice because this imaging can provide molecular information such as histological characteristics.