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Abstract #4134

Characterizing Unilateral Ureter Obstruction of Mouse Kidney with Chemical Exchange Saturation Transfer and Magnetization Transfer Methods

Feng Wang1, 2, Zhongliang Zu1, 2, Keiko Takahashi3, John C. Gore1, 2, Raymond C. Harris3, Takamune Takahashi3, Christopher C. Quarles1, 2

1Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States; 2Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States; 3O'Brien Mouse Kidney Physiology and Disease Center, Vanderbilt University, Nashville, TN, United States

Chemical exchange saturation transfer (CEST) and magnetization transfer (MT) imaging are sensitive to small molecules with exchangeable protons and macromolecules, respectively. Such methods could complement the physiological information obtained from conventional assays of kidney function and facilitate our understanding of pathological mechanisms in kidney disease. In this study, we used CEST and MT to assess mouse kidney following unilateral ureter obstruction (UUO) to determine if these methods are sensitive to the associated pathology.