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Abstract #4149

The Effects of Region of Interest Errors on Estimates of Whole-Body Tumour Volume and ADC in Patients with Bone Metastases.

Matthew D. Blackledge1, Nina Tunariu1, David John Collins1, Anwar R. Padhani2, Martin O. Leach1, Dow M. Koh1

1CRUK and EPSRC Cancer Imaging Centre, Institute of Cancer Research, Sutton, Surrey, United Kingdom; 2Paul Strickland Scanner Centre, Mount Vernon Hospital, Northwood, Middlesex, United Kingdom

We derive the intra-observer repeatability (Bland-Altman statistics) of two radiologists reporting median ADC and total diffusion volume estimates derived from whole-body diffusion-weighted imaging (WBDWI) in a cohort of nine patients with bone metastases. Good repeatability in the range -13.5 to 15.6% is found for ADC estimates and -44.2% to 79.3% for volume estimates. Clinical changes of these parameters in response to treatment are shown to be greater than the repeatability limits observed, as demonstrated in a pilot cohort of 13 patients with bone metastases.