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Abstract #4154

Uniform and Reproducible ADC Measurement on Liver

Tetsuo Ogino1, 2, Toshiaki Miyati, Marc Van Cauteren3, Tomohiko Horie4, Yutaka Imai5

1Healthcare department, Philips Electronics Japan, LTD, Minato-ku, Tokyo, Japan; 2Division of Health Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan; 3Philips Healthcare LTD, Minato-ku, Tokyo, Japan; 4Dept. of Radiology, Tokai University Hospital, Isehara, Kanagawa, Japan; 5Radiology, Tokai University, Isehara, Kanagawa, Japan

A novel method to combine Breath holding, cardiac triggering and double bipolar diffusion gradient is proposed to improve reproducibility of liver ADC measurement. With conventional respiratory triggering DWI, left lobe of liver ADC is artificially elevated by cardiac motion and suffer from poor reproducibility. The proposed method eliminating the cardiac motion effect reduced left/right lobe normal parenchyma ADC difference to 3% from 70 % of conventional respiratory triggering method. 20 slices were acquired with 4 inspiration breath holdings of 10-20 seconds duration. It allows uniform and reproducible ADC measurement in clinically feasible scan time.