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Abstract #4156

Correlation Study of Quantitative Diffusional Kurtosis Imaging with Serum Indicators in Liver Fibrosis

He Wang1, Naiyi Zhu2, Fuhua Yan2, Guang Cao, Xu Yan3

1MR Research China, GE Healthcare, Shanghai, China; 2Department of Radiology, Ruijin Hospital, Shanghai, China; 3East China Normal University, Shanghai, China

Diffusional kurtosis imaging has shown promising results in studies of human brain aging and brain tumor characterization, however, limited results were reported on liver diseases. This study is to investigate the clinical feasibility of DKI in evaluating liver fibrosis by comparison with serum fibrosis indicators. As a result, FA MD, Da and Dr exhibited statistically significant correlation with LN. In addition, compared with another serum indicator HBsAg, moderate correlations were found in Da, MK and Ka. Kurtosis parameters had stronger correlations with HBsAg than normal diffusion parameters.