Evaluation of Effective Regions in Deep Brain Stimulation Using MR-Based Current Density Imaging (MRCDI): In Vivo Canine Brain Study

Munish Chauhan¹, Saurav ZK Sajib¹, Woo Chul Jeong¹, Hyung Joong Kim¹, Oh In Kwon², Eung Je Woo¹

Deep brain stimulation (DBS) is widely used technique for the treatment of various movement disorders such as dystonia, tremor, and Parkinson disease. Due to the inherent limitations of the imaging modalities, physicians cannot diagnosis the exact response of the brain tissues during the stimulation. Recent MR-based current density imaging (MRCDI) technique enables us to estimate the current density distribution using one component of the measured magnetic flux density data. Applying MRCDI technique to DBS, we can predict the current pathway and volume tissue activation which could be useful information for adjusting the electrode parameters and neuronal surgical planning.