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Abstract #4195

Can We Use Simple Linear Model for the Relaxometry to Represent the Concentration of Metal Ions?

Chih-Ching Lai1, Fu-Nien Wang1

1Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan

Iron (Fe) and copper (Cu) are essential elements important for metabolism and biochemical functions in brain. In this study, we design a phantom experiment to investigate whether the relaxation rates of Fe and Cu solutions could be modeled as a linear combining relationship. We observed that the relaxation rates of Fe2+ and Cu2+ mixed solutions could be predicted successfully by measuring R1 and R2 of Fe2+ and Cu2+ solutions respectively. However, the nonlinear R1 and R2 of Fe3+ were improper for linear model. Care should be taken as using relaxometry to represent the concentration of metal ions.