Junyu Guo1, Qing Ji1, Wilburn E. Reddick1
1Division of Translational Imaging Research, St Jude Children Research Hospital, Memphis, TN, United States
Myelin water imaging is a promising technique for evaluating white matter diseases. Poor image quality and a long acquisition time are major obstacles to practical clinical applications. In this study, a novel postprocessing method with an efficient multi-slice acquisition scheme, called T2 spectrum analysis using a weighted regularized non-negative least squares algorithm and non-local mean filter (T2SPARC), is presented to overcome these obstacles. In vivo results from healthy volunteers and a patient with leukoencephalopathy showed that the T2SPARC method can generate robust and high-quality myelin water fraction (MWF) maps of 10 slices within 11 minutes.