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Abstract #4215

Acceleration of Spin-Locked 3D GRE Acquisitions for Rapid T1rho Mapping of the Brain

Casey P. Johnson1, Daniel R. Thedens1, Vincent A. Magnotta1, 2

1Radiology, University of Iowa, Iowa City, IA, United States; 2Psychiatry, University of Iowa, Iowa City, IA, United States

Acceleration methods are assessed for 3D T1rho mapping of the brain. It is demonstrated that substantial reductions in acquisition time (R>5) can be realized while largely retaining T1rho contrast detectability. The use of only two vs. four spin-lock times is also shown to be highly effective, particularly when combined with high degrees of undersampling, yielding net sampling reductions of R>10. The methods demonstrated in this work may greatly improve the utility of 3D T1rho mapping of brain diseases such as Alzheimers and Parkinsons while also enabling state-based dynamic imaging studies such as investigations of stimulus-induced T1rho-sensitive pH fluctuations.