Florian Maier1, David T. A. Fuentes1, Joshua P. Yung1, 2, Kamran Ahrar3, John D. Hazle1, R. Jason Stafford1
1Department of Imaging Physics, The University of Texas M. D. Anderson Cancer Center, Houston, TX, United States; 2The University of Texas Graduate School of Biomedical Sciences, Houston, TX, United States; 3Department of Interventional Radiology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, United States
Recently, a new physics-based method for referenceless proton resonance frequency shift thermometry was presented, which estimates background phase by solving the Dirichlet problem in a circular region of interest. In this work, we modified this algorithm to enable arbitrary regions of interest. The algorithm was tested with in vivo data of laser induced interstitial thermal therapy of human liver. For common ROIs in a 2D image a processing time of less than 0.1 s was found. In conclusion, the proposed algorithm enables definition of arbitrary ROIs and does not restrict users to circular ROIs.