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Abstract #4310

MR Guided High Intensity Focused Ultrasound Bone Ablation Assessed with MR, PET, and MDCT Imaging

Matthew Bucknor1, Viola Rieke1, Youngho Seo1, Randall Hawkins1, Mark Wilson1, Sharmila Majumdar1, Thomas M. Link1, Maythem Saeed1

1Radiology & Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States

MR-guided high intensity focused ultrasound (MRgHIFU) is a powerful technique for thermally ablating focal lesions. The purpose of this study was to clearly delineate post-treatment changes in bone following HIFU on MR, PET and MDCT imaging in a swine model. Two discrete ovoid lesions were created at each proximal diaphysis and distal metadiaphysis of the right femur. Follow-up imaging studies at five days demonstrated focal ovoid hypoenhancement and decreased radiotracer uptake (dynamic 18NaF-PET) which correlated precisely to the prescribed targets. CT failed to demonstrate the lesions. This study supports the usage of MRgHIFU in treating focal lesions in bone.