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Abstract #4456

Quantification of Aortic Pulse Wave Velocity in Preterm Infants Using 4D Phase Contrast MRI

Kathryn M. Broadhouse1, 2, Anthony N. Price1, 2, Giuliana Durighel1, Anna E. Finnemore1, 2, David J. Cox1, 2, A. David Edwards1, 2, Joseph V. Hajnal1, 2, Alan M. Groves1, 2

1Imaging Sciences Department, MRC Clinical Sciences Centre, Imperial College, London, United Kingdom; 2The Centre for the Developing Brain, Imaging Sciences & Biomedical Engineering Division, King's College, London, United Kingdom

A significant increase in pulse wave velocity (PWV) has been found in paediatric subjects born prematurely at low birth weight when studied at ~8yrs and may explain the increase in cardiac disease in this population. However PWV data does not extend back to preterm infants. The aim of this study was to assess the feasibility of measuring aortic PWV in preterm and term infants using 4D PC MRI, in order to establish a normative range in this population and facilitate comparison with adult values. PWV velocity in neonates was found to be at the lower end of reported adult ranges.