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Abstract #4502

Helix Angle (HA) Healthy Statistical Average Technique for HA Quantification in vivo Cardiac Diffusion Tensor Imaging

Pedro Ferreira1, Sonia Nielles-Vallespin2, Peter David Gatehouse1, Ranil de Silva1, Jennifer Keegan1, Peter Speier3, Thorsten Feiweier4, Timothy G. Reese5, Tevfik Ismail1, Andrew Scott1, Choukri Mekkaoui5, David E. Sosnovik5, David N. Firmin1

1BRU, Royal Brompton Hospital, London, United Kingdom; 2National Heart Lung and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD, United States; 3MR Application & Workflow Development, Siemens, Erlangen, Germany; 4MR Application & Workflow Development, Siemens AG, Erlangen, Germany; 5Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States

A healthy average HA map was synthesised from a dataset of 10 healthy volunteers, matching the myocardial shape of the DTI data being analysed. This map allows for a direct pixel-by-pixel comparison of the cardiac fibres orientation in vivo. This technique was subsequently applied to evaluate the improved accuracy of in vivo cardiac DTI data sets based on numbers of averages, together with mean diffusivity and fractional anisotropy quantitation.