Meeting Banner
Abstract #4507

Magnetization Transfer Encoded Steady State Cardiac Imaging of Fibrotic Development in Mice

Moriel Vandsburger1, Katrien Vandoorne1, Michal Neeman1

1Weizmann Institute of Science, Rehovot, None, Israel

The emergence of fibrotic tissue in the heart typically occurs either following myocardial infarction (MI) or accompanying heart failure. Fibrotic collagen generates significant magnetization transfer (MT) effects across a broad frequency range with surrounding water molecules. We sought to exploit the MT properties of collagen, using a novel free breathing retrospectively gated MT-encoded steady state cardiac cine method, in order to quantitatively and non-invasively image fibrotic scar formation following MI in mice.