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Abstract #4509

A Comparative Study of Myocardial T1 Maps and PSIR Images in Measuring Extracellular Volume Fraction at 3T

Mao-Yuan Marine Su1, Lian-Yu Lin2, Chin-Cheng Chang3, Jiunn-Lee Lin2, Wen-Yih Isaac Tseng1, 4

1Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan; 2Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; 3Department of Internal Medicine, National Taiwn University Hospital, Taipei, Taiwan; 4Center for Optoelectronic Biomedicine, National Taiwan University College of Medicine, Taipei, Taiwan

In this study, we examined the compatibility of myocardial T1 maps and reconstructed images of phase-sensitive inversion recovery (PSIR) in measuring extracellular volume fraction (ECV) at 3T. Patients with systolic heart failure (SHF) showed significant higher ECV than patients with diastolic heart failure (DHF) and healthy volunteers (Control) which measured from T1 maps (0.310.03 vs. 0.280.02, p=0.004; 0.310.03 vs. 0.270.03, p = 0.003) and PSIR images (0.300.03 vs. 0.220.03, p<0.001; 0.300.03 vs. 0.220.04, p<0.001). There was no significant difference on ECV measurement between DHF and Control for both methods. A significant correlation was found on ECV measurement between two methods (r = 0.50, p = 0.001). In conclusion, PSIR images provide compatible measurement of myocardial ECV as T1 maps at 3T.